Space-based organ tissue aging and drug screening research
ARPA-H Comprehensive Organ System Modeling in Outer Space (COSMOS) Innovative Solutions Opening, Solicitation ARPA-H-SOL-26-165, issued by Federal (District of Columbia offices).
Key facts
- Issuing agency
- Federal (District of Columbia offices)
- Department
- Dept of Health and Human Services
- Sub-tier
- National Institutes of Health
- Office
- Advanced Research Projects Agency for Health (Arpa-H) (75N992)
- Solicitation number
- ARPA-H-SOL-26-165
- Portal id
- b92d3dc2c5c14c3aac3531c48ad79978
- Type
- Solicitation
- Posted
- Sep 23, 2026
- Response deadline
- Oct 7, 2026, 2:00 PM EDT
- Place of performance
- Nationwide
- NAICS
- 541714
- Product/service code
- AN13
- Official posting
- Documents, addenda and the procurement contact, free with an account.
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Official description
The Advanced Research Projects Agency for Health (ARPA-H) Comprehensive Organ System Modeling in Outer Space (COSMOS) Initiative aims to definitively prove or disprove if exposure to microgravity in Low Earth Orbit (LEO) truly accelerates tissue aging across brain, cardiac, uterine, and kidney tissue types and across several adult age brackets. Provided Tissue Aging Rate in Space (TARIS) exceeds Tissue Aging Rate on Earth (TAROE) at a rate that exceeds the on Earth breakeven cost for new drug R&D, COSMOS will create a first-in-class platform for fully autonomous, high-throughput drug screening in LEO that would be more cost effective and faster than new drug R&D on Earth. ARPA-H anticipates multiple Other Transaction awards resulting from this announcement. Interested parties are invited to download and review the attached COSMOS Innovative Solutions Opening (ISO) ARPA-H-SOL-26-165 Amendment 01 17 September 2026: This amendment includes updated hyperlinks and information on the updated Solutions summary portal. Questions and Answers 21 September 2026: This Q&A is provided for informational purposes only and does not amend the solicitation. All other questions are due by 23 September 2026 at 5:00PM ET. Amendment 02 23 September 2026: This amendment includes updates to Section 3, COSMOS Details; Section 4, Mandatory Experimental Design; as well as Correction to Figure 2.
Solicitation #ARPA-H-SOL-26-165. Issued by HEALTH AND HUMAN SERVICES, DEPARTMENT OF › NATIONAL INSTITUTES OF HEALTH › ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H). NAICS 541714. Product/Service Code AN13.
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